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High-dose vitamin E is especially important, as it may prevent retinal degeneration and neurological symptoms.98 Recommended vitamin E dosages include 100–300 IU/kg/day in high-dose regimens,81,96 and 50 IU/kg/day as a maintenance dose.84 Even high doses may only raise serum vitamin E levels to approximately 30% of the lower limit of normal

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doi: 10.1002/ijc.21678